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8 Things About CBD Tolerance That You Should Know

Any cannabis connoisseur can attest that excessive marijuana consumption will have declining returns. But why? Well, the body develops THC tolerance, but is it the same for CBD tolerance along with its therapeutic benefits? Both THC and CBD are in cannabis, yet there are differences among the two.

The most notable distinction is that THC will get you stoned while CBD won’t. But the fast facts, there’s a difference and how the body builds up a tolerance to every compound? Continue reading to know what’s going on here.

1. What is Tolerance?

Tolerance is the body’s need for increasing substances to attain the same expected results. Either it’s THC, nicotine, alcohol, or caffeine, we want more in another time to achieve the same effects. It can get right to the point where you feel nothing anymore. However, don’t complicate high tolerance with addiction because that’s more when you want the drug to become “normal” or experience unfavorably from the absence of it.

Tolerance has three major types – cellular, behavior, and metabolic. Cellular tolerance happens when the cells are numb to the mixture and don’t respond and connect the same as before. At the same time, behavioral tolerance is another type of tolerance that adapts you to a drug making it dull or ordinary. And last, there’s metabolic tolerance. The pathway of consumption is not as useful at ingesting the chemicals; thus, the effects are not as strong. You take it differently to achieve those other levels.

2. How to Determine Your CBD Tolerance

Let us first determine a user’s CBD tolerance level before discussing if tolerance to a CBD can be developed as time goes by. 

Every human body is unique, so your reaction to CBD will be different from the next person. Therefore, your path needs to be your own towards developing what CBD potency is for you and your body. 

It is ideal to start slow and build your way up. Start with the smallest potency of CBD products. Regardless of what you choose, make sure it contains below 5% amount or have as little as a 1% amount if you want to guarantee safety.

If you think you can go much higher, start moving your way up progressively, and when you achieve the right amount for you, you should stop. It’s OK not to examine yourself, as there’s no self-esteem to be earned in managing a much higher CBD potency than anyone else can.

If you find the perfect CBD product, stick to it. Thus, it takes us to another question, if you hang on to a similar product, can you develop a CBD tolerance and need a higher dosage later on?

3. What Takes Place In Our Bodies?

The way CBD works with the endocannabinoid system is the basis of why it acts distinctively from THC. Instead of combining with receptors CB1 and CB2, It requires a more indirect method. At Fukuoka University, Department of Neuropharmacology, a study is conducted and discovered that “neuroprotective effects are separated CB1 blockade”, Which implies that the mixture does not have to work by combining immediately with the receptors. It is less susceptible to the tolerance process.

Instead, the mixture can increase the combining relationship of particular receptors and promote the endocannabinoid production, mixtures essential for keeping balance (homeostasis) through the ECS. This process is known as “reverse tolerance” and is utilized to describe why you need less of a drug to experience similar effects and not much higher. 

The ECS or endocannabinoid system is forced to become hyperactive and dismiss the compound after some time. The CBD manages and controls the receptors’ dynamization.

4. Can you Develop a CBD Tolerance? 

CBD and THC are both cannabinoids of the same origin, But they work in entirely different ways. The CBD will not get you” stoned,” but it helps fight depression and stimulate calm sensation. On the other hand, THC will get you high or “stoned” and develop a tolerance fast, while CBD does not have tolerance forming ability. It is like reverse tolerance, which means you only need a little CBD amount when you want more.

CBD functions by combining the CB1 receptors. But it decreases the combining relationship between other cannabinoids and CB1s, which results in becoming less invigorated. While THC functions oppositely, it over stimulates the receptors, resulting in internalization and desensitization. The research on cannabis and CBD are still in its inception. Evidence recommends that you don’t need to be concerned about CBD tolerance buildup.

However, there is still unscientific proof that suggests the reverse and CBD tolerance does transpire. There are numerous reports and Reddit posts, YouTube videos, and a large number of forums claiming how they possess tolerance for CBD build up and that CBD is not functioning as before. 

5. How Reverse Tolerance Works?

The reverse tolerance is the counterpart of tolerance, and it’s also called “drug sensitivity.” When this happens, continuous use of a drug reduces tolerance levels, and the small dosage is needed to get a similar effect. 

Most of the drugs, such as alcohol, nicotine, pharmaceuticals, and illegal drugs, including methamphetamines and cocaine, make most users feel higher tolerance levels. But, in some cases, a few people have claimed the reverse effect. Alcoholics, for example, may build up an alcohol reverse tolerance because of chronic liver damage.

While only a little research has examined the CBD tolerance forming, the agreement is that there’s minimal to the non-existent threat of building it up. The theory establishes that since CBD technically doesn’t combine to any ECS receptor, it blocks the issue of tolerance. 

The THC, on the other hand, reduces cannabinoid receptors in time. CBD helps improve receptor action. Whatever is accountable for the reverse tolerance of CBD, more frequently than not, users find they can progressively reduce their dose after a while. But forum members claim differently.

6. Effect of Long-Term Use of CBD

Until recently, legislation against marijuana and cannabis intake has restricted the number of long studies exploring the constant intake of CBD. Most of the clinical studies on the CBD oil effects do not contribute a testing duration over several months. Inevitably, as legislation on CBD, cannabis, and hemp continue to change, more data is becoming available.

Although there’s a shortage of study on lasting CBD consumption, other research and health studies have yielded potential results towards CBD’s effectiveness and safety. CBD oil is considered to offer small to no danger for dependence or adverse reactions. The WHO or World Health Organization states, “CBD is commonly tolerated well with an ideal safety profile.”

Numerous proofs recommend that CBD is a non-toxic, safer, and more beneficial way to treat problems that need long-lasting treatment, such as depression and severe pain.

7. Other Causes of Losing CBD Potency

Before you increase your dosage level, it’s essential to consider if there are reasons why the CBD you’re using is losing its effectiveness. 

First, examine where your products are from. Currently, CBD products have limited regulation so that lesser reliable retailers may be selling low-quality CBD products. 

There may be no CBD ingredient or has other products that are not labeled. In any case, this can affect the effectiveness of the product.

It is wise to consistently make sure that you’re purchasing CBD products from trusted sources, reliable, attractive, and lingually skillful sources.

The study about CBD tolerance, as in various other CBD parts, is continuing, and once any latest updates are released, sure most CBD companies will inform you immediately.

8. Three Other Distinctions of CBD vs. THC

Tolerance forming is one of the significant differences between the two, but there are extra three. The increasing popularity of CBD is due to its essential difference between the two.

  • CBD doesn’t cause psychedelic effects, yet it’s a different story with THC.
  • CBD can alleviate anxieties and depressions, while THC can provoke such ailments.
  • The legal predicament that THC presently considers itself in, particularly in the US. All hemp-based CBD products are exempted from that problem, thankfully.

The ongoing study on CBD tolerance mainly emphasizes the distinctions between CBD and THC. If you think you could be building up a tolerance to CBD, it’s worth checking the recommendation of a health doctor knowledgeable d in CBD treatment.


Studies seem to show that CBD isn’t tolerance-building, and in actuality, contain reverse tolerance effects. This means always taking CBD can lead to users wanting less of CBD to get the same effects. It looks CB1 cells do not withstand harmful allosteric inflection in the same manner they reject full direct stimulation. Also, considering CBD’s special connection to receptors CBD1, It helps control the THC tolerance building pattern. Joint smokers worried about tolerance would be smart to include some CBD to their cannabinoid routine.

More studies are required to confirm the “reverse tolerance” theory. However, the proof recommends that CBD consumers not worry about tolerance. Thus, this is amazing, particularly since CBD’s wide variety of beneficial effects, most of the problems it discourses are treated With potent treatments that are tolerant. CBD shortage of tolerance forming is another interesting point for this wonder cannabinoid.

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